Human trafficking is an aged-long problem in human society. It however assumed an alarming proportion in contemporary society particularly, in Nigerians’ economic and socio-political relations with other nations of the world. Scholars of different orientations have attempted to provide lasting solution to this organised criminal activity that treats humans as article to be purchased, controlled and exploited. To date scholars’ efforts have not yielded the desired results; hence, the nature and scope of the illicit trade is on the increase. This study therefore, sought an adequate philosophical foundation upon which the menace could be constructively handled. Hence, Immanuel Kant’s Categorical Imperative is adopted as the theoretical framework for this study. The study adopts the qualitative method of philosophical inquiry. Specifically, it employed the critical, and analytical tools to interrogate human trafficking in Nigeria and proffer metaphysically inclined solution. The study revealed that the essence of human beings particularly, the humanity principle which enjoys a person to treat another as an end in itself and not as mere means is a solid and adequate foundation upon which interpersonal relations of moral agents could be based in handling constructively the problem of human trafficking in Nigeria. The study concluded that the respect for the dignity of the human person should not be compromised under the guise of economic advantage or other social benefits accruable to the practitioners of acts that exploit and dehumanise the human person.